Asthma treatment to treat Alzheimer’s

 

Kathryn Vaughan

New research into has raised the possibility of treating Alzheimer’s disease with drugs currently used by asthmatics.

Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common cause of dementia. Often diagnosed in people over 65 years of age, symptoms include inability to recall recent events, confusion, aggression, long-term memory loss and irritability. As the disease progresses bodily functions also deteriorate, ultimately leading to death.

The cause(s) of AD is not well understood and as such there are no treatments available to cure or delay the progression of the disease. Research characterises the disease by the development of plaques and the deposition and aggregation of proteins within neurons of the brain, leading to neurone degradation. These are thought to arise by both genetic and environmental factors. Amyloid, a fibrous protein, has been identified as a major component in these deposits, and is formed by the processing of a precursor protein by secretase enzymes. The secretase is composed of 4 membrane proteins, which are transcribed upon the activation and nuclear translocation of CREB (cAMP Response Element Binding).

A recent study from Temple University, School of Medicine, Philadelphia, has implicated the enzyme 5-lipoxygenase (5-LO) in AD. This enzyme catalyses the conversion of arachidonic acid to 5-hydroxy-peroxy-eicosatetraenoic acid (5-HPETE), and subsequently to 5-hydroxy-eicosatetraenoic acid (5-HETE).  The eicosanoid 5-HETE is an intermediate for leukotriene synthesis, where leukotrienes are lipid mediators that are important in the inflammatory response.

The research group, led by Dr Domenico Praticó, used both pharmacological and genetic approaches to show that 5-LO may provide better understanding of the processes leading to AD. They found that the expression of 5-LO is greater in AD patient brains compared to healthy controls and that knocking-out the 5-LO gene in a mouse model of amyloidosis (accumulation of insoluble amyloid protein) significantly reduced the levels of amyloid and secretase, without drastically affecting other biological processes.

This potentially establishes a novel role for 5-LO in regulating amyloid levels. If you can control the levels of secretase, the only source of amyloid in the brain, then you can control amyloid levels and hence AD. Thus 5-LO may provide a potential target for the treatment of AD by use of 5-LO inhibitors that are currently used for the treatment of asthma.

Chu and Praticó (2010) 5-Lipoxygenase as an endogenous modulator o amyloid beta formation in vivo. Annals of Neurology

Plant help signals intercepted by the enemy

Izzy Dean

A recent talk given at the University of Sheffield by Harro Bouwmeester gave an fascinating insight into the secret life of parasitic  plants. The word parasite commonly brings up images of fleas, ticks and worms but parasitism is also rife in the plant kingdom. Parasitic plants can have a large effect on crops, causing devastating effects particularly in poorer third world farming communities.

 Some plant parasites, such as Witchweed and Broomrape, have evolved to become completely dependent on the plant which they parasitise and these parasites are unable to survive in absence of a host.  Parasite seeds often remain dormant for long periods of time, only germinating if a potential host plant is nearby. The parasite then grows through the soil towards the host plant and attaches to the roots of the plant, before piercing the host root and obtaining nutrients through this attachment.

Scientists, from Wageningen University in the Netherlands, discovered that parasitic plants can recognise certain chemicals released by roots of potential host plants. This group of plant hormones, named strigolactones, allow parasites to detect and locate host plants so they can time germination and the direction of initial growth accurately.

Ironically, Strigolactones are released with the intention to attract assistance from a special group of helpful fungi. These fungi, which also attach to the plant root, provide critical nutrients from the soil in exchange for the carbon they take from the plant. Plants growing in soils which are low in nutrients such as phosphorus have a higher dependency on fungi partnership and so release higher amounts of strigolactones.  

These findings have important implications for regions with low quality soil, such as areas of Africa, where striga is a major problem. Research into the production of strigolactones in plants is ongoing, but it appears that strigolactones may have a secondary function, making suppression of these chemicals in prevention of parasites difficult.

For more information: http://www.plantphysiol.org/cgi/content/short/139/2/920

A little Introduction….

First things first, welcome to this new Physics and Astronomy Blog.

 

In starting this blog I am to inform about various discoveries happening in the world of Physics and Astronomy giving any extra background where necessary for anyone not totally familiar with the subject, this may manifest itself as an article or a round up of the week in Physics. When time allows I will probably even do some subject reviews focusing on previous research and fundamental theories and maybe even include some book/documentary reviews (although I make no promises about the frequency of these!).

 

I hope that this blog ends up being informative and any suggestions I will take onboard and try to answer or fulfill.

 

Cheers.

Seeing shapes, touching shapes… Hearing shapes?

Maria Panagiotidi

“Can shape be represented by sound artificially?” That is the question that Jung-Kyong Kim  and Robert J. Zatorre posed in their recent study published in October’s Experimental Brain Research Journal.

Shape is an inherent property of objects that we encounter in our everyday life. It is thought to be experienced mainly through vision and touch. Previous experiments suggest that sound can also convey visual information by means of image-to-sound coding. This is similar to echolocation, a system that allows species such as bats to navigate and identify objects.  It has also been used as an alternative way to allow people with impaired vision to experience the world.

In this study, scientists from McGill University in Montreal investigated whether sound can code tactile information. They did this by blindfolding sighted participants and training them to recognise spatial information using specially-coded sounds. These sounds represented information of abstract shapes. After the training session, the participants were tested on old (previously learned) and new subjects. It was found that they were able to match auditory input to tactually discern shapes meaning that they could use sounds to “see” shapes. 

The results from this study provide evidence for the hypothesis that the perception of a coherent object or event ultimately occurs at a highly abstract level in a form independent of the sense from which it was perceived. In addition to that, this approach could possibly lead to the development of new methods aiming to aid individuals with impaired vision.

 

Original article: Jung-Kyong Kim, Robert J. Zatorre. Canyou hear shapes you touch?Experimental Brain Research, 2010; 202 (4): 747 DOI: 10.1007/s00221-010-2178-6

Weird Physics – an Introduction

Guest post By Robin Bisson

 

With Halloween and Bonfire Night out of the way, mince pies comfortably established on the supermarket shelves and town light displays ready to be switched on by a passing celebrity, Christmas is on the horizon. And so too is Science Brainwaves’ Christmas Lecture, a free event being held on the 17th on December at the University of Sheffield, which promises to be a real cracker *groan*. The lecture, titled ‘Weird Physics’, is being given by Dr Paul Stevenson of the University of Surrey.

That physics is weird might seem to be a given, after all physics fans have a reputation for getting all excited over obscure things that happen millions of light years away, having some outlandish tastes in music, and developing a tendency in later life to wear jackets with leather elbow patches. However, we’re not talking about any normal kind of weirdness here; we’re talking about the seriously bizarre world of quantum mechanics, a world in which even the most basic facts about the world get turned upside down. Now, if all that the word ‘quantum’ makes you think of is daytime repeats of Quantum Leap, you’re probably not alone. So to get swotted up before the lecture, and to give you a taste of some of the strangeness to come, here’s an introduction to the weird world of quantum mechanics…

Perhaps the most well known illustration of why the quantum world is at odds with the rest of the world is that of Erwin Schrödinger’s famous cat. Schrödinger proposed an experiment where a cat is placed in an opaque box, in which there would also be a phial containing poisonous gas, one radioactive atom and a mechanism to smash the phial if the atom decayed. If the atom were to decay then the cat would die, but if the atom does not decay then the cat survives. The weirdness comes in because quantum mechanics tells us that until we look at the atom, it is in the state of being decayed and non-decayed at the same time, and the consequence for our unhappy cat is that it is both alive and dead at the same time. “Ridiculous!” you might well shout, which is exactly what Schrödinger was pointing out, all be it in a slightly morbid way – the quantum world does not appear to fit in with the world of big things that we know, in which cats most definitely don’t wander about in limbo between life and death.

To make it clearer what exactly we’re dealing with here, a little explanation is needed. The quantum world is that of atoms and subatomic particles: the familiar electrons, protons and neutrons that we all learned about at school, as well as other more exotic particles. One of the things that quantum mechanics says about these little bits of matter, is that once you have observed them being in a particular place at a particular time, you cannot say for sure exactly where they will be at any point in the future. Instead you can only give a probability of them being in a particular place until you have another look and make sure. So far so normal. After all, we can’t expect to know everything.

What quantum mechanics sneaks in and confuses us with, however, is the assertion that these particles aren’t actually anywhere until we look to check – while our backs are turned they are in one place, and another place, and even another, and another and another place all at the same time, but when we look at them BANG, they are somewhere definite again. It’s a bit like playing “What’s The Time Mr. Wolf?” with subatomic particles, except that instead of you not knowing where your fellow players are, they don’t know where they are until you turn around to look (and also, subatomic particles don’t run away screaming when you growl at them).

If this all seems a bit stupid and it’s obvious that physicists just haven’t understood some basic stuff, like that things can’t be in two places at once, there are some awkward experimental results that show the quantum world simply can’t be like the world we all know and love. For instance, quantum particles get ‘entangled’ with each other, so that if you do something to one of the particles the other particle notices. It doesn’t matter if the other particle is on the other side of the room, the other side of the world or the other side of the universe, it will ‘respond’ when its partner has something done to it. Weirder still, these particles may not even only be particles – quantum mechanics regards them as having some properties of waves, and some properties of particles, something that Richard Feynman called “the only mystery in physics”.

Don’t worry if your brain is beginning to throb alarmingly, the physicists are confused too. Since quantum mechanics was first formulated there has been a raging debate about how it should be interpreted. One interpretation that has steadily gained support is that quantum mechanics only makes sense if we live in just one of many co-existing parallel universes. Every time we look in the box to see the mortal state of Schrödinger’s cat we set off down one leg of the trousers of time, let’s assume the one where the cat is alive, while in the universe of the other leg, the cat has met a sticky end.

While it may be mind-bending to try and understand what quantum mechanics implies about the universe and to imagine what the quantum world looks like up close, the more we understand about it, the more we can manipulate it to do some pretty nutty things. We all know that as long as watertight bowls are kept steady, any liquid inside them is going to stay there, right? Not if it’s a superfluid – liquids predicted by quantum mechanics that creep slowly out of any container holding them (click the link for a video). Even more amazingly, there is some early evidence that supersolids can exist – solids that literally move through each other like ghosts, without being affected. In any case, I think we can all agree that a world with quantum mechanics is a much weirder world indeed than a world without. To find out more, come to the Christmas Lecture, but don’t say you weren’t warned if you lose grip on reality…

 

 

If you want to investigate Quantum Mechanics further, then check out plus magazine’s website for podcasts, news and reports.

Scientists discover how to regenerate damaged heart muscle cells

Claire Tree-Booker

Scientists have uncovered how to turn common heart cells into beating muscle cells.

Around 68 000 people suffer from heart failure annually in the UK, because the heart is unable to repair itself after an attack.

The muscle cells that cause the heart to beat, called cardiac myocytes, die during a heart attack and are replaced by non-beating connective tissue cells, called fibroblasts. This loss of beating muscle cells means that the heart is no longer able to pump as effectively.

Researchers Deepak Srivastava and Masaki Ieda from the Gladstone Institute of Cardiovascular Disease in California investigated whether they could turn fibroblasts into beating cardiac myocytes.

The scientists put several genes known to be important in heart development into mouse cardiac fibroblasts, to see whether they would change into myocytes.

The technique, known as cellular reprogramming, worked successfully and three genes were identified that altered the cells.

After one month of treatment with extra copies of the three genes, known as Gata4, Mef2c and Tbx5, around 20% of the fibroblasts had the characteristics of myocytes, and began to contract like beating heart cells.

In the 6th August issue of Cell, the scientists showed that the reprogrammed cells had proteins on their surface that are normally found in cardiac myocytes, and they expressed similar genes.

The researchers’ next step is to test whether the same genes can be used in human hearts; “I envision such factors being loaded onto a stent that is placed in the coronary artery”, says Professor Srivastava. He believes it is “not unreasonable to imagine being ready for a clinical trial in the next five years”.

Nuclear Power – A brief history

Today’s society consumes more energy than ever, and energy demand will continue growing as bigger, better and faster technologies are introduced. Energy consumption rate has risen by over 50% in the past 20 years.  The pressing issue here is that renewable energy sources (solar, wind, hydro etc.) are not providing sufficient energy to meet demand and non-renewable sources (Coal, Crude Oil etc.) are inevitably coming to an end. Furthermore the production of greenhouses gases impacts the climate thus further complicating matters and adding to the problem. Therefore, there has never been a more crucial time for the utilisation of nuclear energy. This type energy is generated as a result of controlled nuclear reactions i.e. nuclear fission, and can be used in various ways, be it in reactors or even in bomb making!!

In order to understand the impacts of nuclear energy, it is useful to first explore its history and how it was received by the general public. This will build a good foundation to allow analysis of recent issues and problems presented by nuclear energy, exactly what caused these problems and how harmful or disastrous they could be. Once the problems are recognised, it is vital that they be addressed, after detailed investigation, with solutions such as suitable waste immobilisation. It will also allow for discovery and evaluation of the great benefits nuclear energy introduces and the great impact this has on the economy and the environment. In this Nuclear blog I aim to discuss and investigate nuclear energy as a replacement energy source as well as how it can be coupled with renewable energy to meet the economic constraints of today’s society and most importantly how the waste it produces can be immobilised efficiently. It will also explore how, over history, nuclear energy was manipulated in the production of nuclear weaponry i.e. the atomic bomb.

To get things rolling I want to start this blog with a report on the brief history of nuclear energy. Nuclear energy dates back to late 1800’s. To be exact ionising radiation was discovered by Wilhelm Rontgen in 1895 producing continuous x-rays by passing an electric current through an evacuated glass. Progressive steps were taken in the research of radiation until 1902 when Ernest Rutherford illustrated that radioactivity creates a different element by emitting an alpha (2 protons & 2 neutrons) or beta particle (an electron) from the nucleus. To understand how this works let’s look at an atom of nitrogen.

Nitrogen Atom (N)
Ernest Rutherford

The yellow spheres are the protons, and the orange spheres are the neutrons, combined they form the nucleaus and give the atom its mass number (mass number = protons + neutrons). Nitrogen contains 7 protons (carrying a positive charge) and 7 neutrons with a mass number of 14. The 7 small white spheres orbiting the nucleas in shells are the electrons (carrying a negative charge). These numbers characterise the nitrogen atom, therefore if they are altered there would be changes in the element.  Using this research Rutherford illustrated, in 1919, that all the particles fired from a radium source into nitrogen could form oxygen as a result of the nuclear rearrangement. He fired alpha particles (2 proton & 2 neutrons) at the nitrogen atom, this in turn increased the amount of protons and neutrons in nitrogen from 14 to same amount as in an isotope (an atom of an element with the same number of protons but different number of neutrons) of oxygen, and thus the element was converted from nitrogen to oxygen.

In the 1930s research accelerated and scientists were experimenting with bombarding atoms with protons and neutrons in order to create artificial radionuclides. It was also illustrated that upon bombardment of the nucleus with the neutron, the neutron is captured causing severe vibration and leading the nucleus to split into two not quite equal parts thus releasing significant amounts of energy. This is called nuclear fission and it was discovered this fission reaction could release further more neutrons which in turn would lead to more fission resulting in a vast amount of energy being released. Since its discovery nuclear energy, used with bombs and reactors, has been received with great controversy. It is associated with mutation, atomic weapons and universal doom. It is a prime example of irrational public fear of a misunderstood technology. This is illustrated by a recent survey undertaken in America and Japan showing that reactor accidents evoked more feelings of dread amongst the public than any other modern risk, including problems that harm millions of people annually. Also in the early days nuclear scientists were seen as alchemists due to the misunderstanding of the transmutation capabilities of nuclear science. This misunderstanding led to the labeling of nuclear energy as the ‘elixir of life’ in the early 20th century. Such an ideology was reinforced by the discovery that radium was useful in treating certain types of cancer, however the press reported that radium was capable of fully conquering all types of cancer (media hype). By the 1930s radium was included in pastes, powdered pills, tonics and even mineral waters to cure baldness, restore youth etc. However the public eventually came to learn that radium has as much chance of causing mutations and cancer as treating it. Up until this point nuclear energy was only seen to be useful for medicinal purposes, however over the late 20th century nuclear fission energy was harnessed and used in several ways, with the main use being in the nuclear fuel cycle delivering the nuclear energy we know today. Nuclear fission occurs when a heavy atomic nucleus breaks into smaller pieces (decay) releasing energy. This process can also be accelerated by bombardment of the nucleus with neutrons. Let’s take for example uranium, the most stable isotope has a mass number of 238 (146 protons + 92 neutrons) and is the slowest decaying. Uranium 235 decays slightly faster, however is still relatively stable. If we were to bombard U-235 with neutrons, the neutron would attach to the nucleus and form U-236, a very unstable isotope. This decays rapidly into an atom of barium and krypton. This is called induced fission. This is illustrated in the diagram below.

Bombarding a Nucleus with a Neutron to create Induced Fission

Nuclear scientists manipulated this energy and began using it in nuclear reactors. In 1951 the Experimental Breeder Reactor illustrated electric power can be generated from a nuclear source demonstrating the possibility of breeding plutonium. It was also illustrated that the water in reactor can be left to boil thus generating steam directly. However there was scepticism regarding the dangers of the instability associated with the boiling. As a result BORAX tests were undertaken to show that boiling reactors can operate safely and as a result further work was implemented illustrating electrical generation in 1955. This resulted in the commercial manufacture of boiling water reactors with the first being put into operation in Illinois, USA in 1960. Research in the USA led to the discovery of the pressurised water reactor with the first being used to produce commercial electric power at Pennsylvania USA in 1957. These reactors have been enhanced and improved through the year up until today, to produce the nuclear energy we know and hate/love (?).